These findings suggested a role of T cells in ACS and provided a new way to explore the mechanisms of ACS.Īcute coronary syndrome (ACS) is the severe form of coronary artery disease (CAD), which remains the leading cause of morbidity and mortality worldwide.

This study revealed the distinct TCR repertoires in patients with ACS and demonstrated the presence of disease associated T-cell clonotypes. We identified some shared CDR3 amino acid sequences that were presented in ACS but not in NCA patients. A total of 10 V genes and 1 J gene were differently utilized between ACS and NCA patients. The clonotype overlap of complementarity determining region 3(CDR3) was significantly varied between different groups. ACS patients presented higher levels of clonal expansion. ResultsĪCS patients including UA and AMI, showed reduced TCRβ diversity than NCA patients. The clonal diversity of the TCR repertoires in different groups was analyzed, as well as the frequencies of variable (V), diversity (D) and joining(J) gene segments. The TCR repertoires of 9 unstable angina patients (UA), 14 acute myocardial infarction patients (AMI) and 9 normal coronary artery (NCA) patients were profiled using high-throughput sequencing (HTS). This study aims to investigate the T-cell receptor (TCR) repertoire in patients with acute coronary syndrome (ACS).

T cell repertoire